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cenobamate will increase the level or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Watch Intently. Look at a dose reduction of CYP2C19 substrates, as clinically correct, when used concomitantly with cenobamate.iloperidone boosts amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Wa